Detalhe da pesquisa
1.
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.
Cell
; 166(6): 1423-1435.e12, 2016 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27594426
2.
Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross.
PLoS Pathog
; 16(2): e1008363, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32069335
3.
Malaria parasite plasmepsins: More than just plain old degradative pepsins.
J Biol Chem
; 295(25): 8425-8441, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32366462
4.
Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes.
Cell Microbiol
; 20(10): e12868, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29900649
5.
Activation of the Plasmodium Egress Effector Subtilisin-Like Protease 1 Is Mediated by Plasmepsin X Destruction of the Prodomain.
mBio
; 14(2): e0067323, 2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37036362
6.
Activation of the Plasmodium egress effector subtilisin-like protease 1 is achieved by plasmepsin X destruction of the propiece.
bioRxiv
; 2023 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36712005
7.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Nat Commun
; 14(1): 1455, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36927839
8.
An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum.
Sci Rep
; 11(1): 342, 2021 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33431920
9.
Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V.
ACS Infect Dis
; 6(4): 738-746, 2020 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32069391
10.
Fast-Acting Small Molecules Targeting Malarial Aspartyl Proteases, Plasmepsins, Inhibit Malaria Infection at Multiple Life Stages.
ACS Infect Dis
; 5(2): 184-198, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554511
11.
4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.
J Med Chem
; 62(7): 3503-3512, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30856324
12.
EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX.
Nat Microbiol
; 3(10): 1090-1098, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30150733
13.
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.
Science
; 358(6362): 518-522, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074774
14.
Synthetic RNA-protein modules integrated with native translation mechanisms to control gene expression in malaria parasites.
Nat Commun
; 7: 10727, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26925876